View source for 22rq


==Human KCNQ3-XEN1101 complex in the presence of PIP2==
<StructureSection load='22rq' size='340' side='right'caption='[[22rq]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[22rq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=22RQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=22RQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EY8:~{N}-[4-(6-fluoranyl-3,4-dihydro-1~{H}-isoquinolin-2-yl)-2,6-dimethyl-phenyl]-3,3-dimethyl-butanamide'>A1EY8</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=22rq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=22rq OCA], [https://pdbe.org/22rq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=22rq RCSB], [https://www.ebi.ac.uk/pdbsum/22rq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=22rq ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/KCNQ3_HUMAN KCNQ3_HUMAN] Benign familial infantile epilepsy;Benign familial neonatal seizures;Juvenile myoclonic epilepsy. The disease is caused by mutations affecting the gene represented in this entry.  Defects in KCNQ3 may be involved in epileptic disorders. These are characterized by paroxysmal transient disturbances of the electrical activity of the brain that may be manifested as episodic impairment or loss of consciousness, abnormal motor phenomena, psychic or sensory disturbances, or perturbation of the autonomic nervous system.<ref>PMID:22612257</ref> 
== Function ==
[https://www.uniprot.org/uniprot/KCNQ3_HUMAN KCNQ3_HUMAN] Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs.
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cheng XY]]
[[Category: Hou PP]]
[[Category: Hu B]]
[[Category: Jiang DX]]
[[Category: Wan SY]]
[[Category: Zhang HY]]
[[Category: Zhang J]]