View source for 23it


==Complex of FMDV O/HN/CHA/93 and porcine-derived neutralizing monoclonal antibody pO18-29==
<StructureSection load='23it' size='340' side='right'caption='[[23it]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[23it]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Foot-and-mouth_disease_virus_O Foot-and-mouth disease virus O] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=23IT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=23IT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.24&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=23it FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=23it OCA], [https://pdbe.org/23it PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=23it RCSB], [https://www.ebi.ac.uk/pdbsum/23it PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=23it ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q00574_FMDVO Q00574_FMDVO] Lies on the inner surface of the capsid shell. After binding to the host receptor, the capsid undergoes conformational changes. Capsid protein VP4 is released, capsid protein VP1 N-terminus is externalized, and together, they shape a pore in the host membrane through which the viral genome is translocated into the host cell cytoplasm. After genome has been released, the channel shrinks.[ARBA:ARBA00033716]
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</StructureSection>
[[Category: Foot-and-mouth disease virus O]]
[[Category: Large Structures]]
[[Category: Sus scrofa]]
[[Category: Lei D]]
[[Category: Wu S]]