View source for 23xk


==Cryo-EM structure of human sodium/proton antiporter NHE1 in complex with Cariporide in an outward-open conformation==
<StructureSection load='23xk' size='340' side='right'caption='[[23xk]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[23xk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=23XK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=23XK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG0:~{N}-[bis(azanyl)methylidene]-3-methylsulfonyl-4-propan-2-yl-benzamide'>HG0</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=23xk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=23xk OCA], [https://pdbe.org/23xk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=23xk RCSB], [https://www.ebi.ac.uk/pdbsum/23xk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=23xk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SL9A1_HUMAN SL9A1_HUMAN] Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.<ref>PMID:8901634</ref> <ref>PMID:11350981</ref> <ref>PMID:15035633</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cong Y]]
[[Category: Kong F]]
[[Category: Yan C]]
[[Category: Zhu A]]