View source for 23xm


==Cryo-EM structure of human sodium/proton antiporter NHE1 in complex with Eniporide in an outward-open conformation==
<StructureSection load='23xm' size='340' side='right'caption='[[23xm]], [[Resolution|resolution]] 3.24&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[23xm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=23XM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=23XM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.24&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1E6D:~{N}-carbamimidoyl-2-methyl-5-methylsulfonyl-4-pyrrol-1-yl-benzamide'>A1E6D</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=23xm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=23xm OCA], [https://pdbe.org/23xm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=23xm RCSB], [https://www.ebi.ac.uk/pdbsum/23xm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=23xm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SL9A1_HUMAN SL9A1_HUMAN] Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.<ref>PMID:8901634</ref> <ref>PMID:11350981</ref> <ref>PMID:15035633</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cong Y]]
[[Category: Kong F]]
[[Category: Yan C]]
[[Category: Zhu A]]