View source for 24ti


==Cryo-EM structure of the PCO371-bound GHRHR-Gs complex==
<StructureSection load='24ti' size='340' side='right'caption='[[24ti]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[24ti]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=24TI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=24TI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.88&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KHF:1-[3,5-dimethyl-4-[2-[[4-oxidanylidene-2-[4-(trifluoromethyloxy)phenyl]-1,3,8-triazaspiro[4.5]dec-1-en-8-yl]sulfonyl]ethyl]phenyl]-5,5-dimethyl-imidazolidine-2,4-dione'>KHF</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=24ti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=24ti OCA], [https://pdbe.org/24ti PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=24ti RCSB], [https://www.ebi.ac.uk/pdbsum/24ti PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=24ti ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/GHRHR_HUMAN GHRHR_HUMAN] Isolated growth hormone deficiency type IB. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:11232012</ref> <ref>PMID:10084571</ref> <ref>PMID:12534354</ref> 
== Function ==
[https://www.uniprot.org/uniprot/GHRHR_HUMAN GHRHR_HUMAN] Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Synthetic construct]]
[[Category: Chen XY]]
[[Category: Chen YY]]
[[Category: Cong ZT]]
[[Category: Hang KN]]
[[Category: Huang ST]]
[[Category: Qiu Y]]
[[Category: Wang MW]]
[[Category: Zhou QT]]