View source for 25ij


==Cryo-EM structure of human Nav1.6 in complex with delta-paraponeritoxin-Pc1a==
<StructureSection load='25ij' size='340' side='right'caption='[[25ij]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[25ij]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Paraponera_clavata Paraponera clavata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=25IJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=25IJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9Z9:(3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en'>9Z9</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PCW:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PCW</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=25ij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=25ij OCA], [https://pdbe.org/25ij PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=25ij RCSB], [https://www.ebi.ac.uk/pdbsum/25ij PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=25ij ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SCN8A_HUMAN SCN8A_HUMAN] Non-specific early-onset epileptic encephalopathy;Self-limited infantile epilepsy;Infantile convulsions and choreoathetosis;Autosomal dominant non-syndromic intellectual disability. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease may be caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/SCN8A_HUMAN SCN8A_HUMAN] Pore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass along their electrochemical gradient (PubMed:24874546, PubMed:25239001, PubMed:25725044, PubMed:26900580, PubMed:29726066, PubMed:33245860, PubMed:36696443, PubMed:36823201). Contributes to neuronal excitability by regulating action potential threshold and propagation (PubMed:24874546, PubMed:25239001, PubMed:25725044, PubMed:26900580, PubMed:29726066, PubMed:33245860, PubMed:36696443, PubMed:36823201).<ref>PMID:24874546</ref> <ref>PMID:25239001</ref> <ref>PMID:25725044</ref> <ref>PMID:26900580</ref> <ref>PMID:29726066</ref> <ref>PMID:33245860</ref> <ref>PMID:36696443</ref> <ref>PMID:36823201</ref>   More specifically expressed in non-neuronal cells, could play a role in sodium release from intracellular compartments and participate in the control of podosomes formation and macrophages adhesion and movement.<ref>PMID:19136557</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Paraponera clavata]]
[[Category: Fan X]]
[[Category: Huang J]]
[[Category: Yan N]]
[[Category: Yang L]]