View source for 25pv


==Structure of the anthrax protective antigen in complex with a potent neutralizing antibody==
<StructureSection load='25pv' size='340' side='right'caption='[[25pv]], [[Resolution|resolution]] 3.03&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[25pv]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=25PV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=25PV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.03&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=25pv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=25pv OCA], [https://pdbe.org/25pv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=25pv RCSB], [https://www.ebi.ac.uk/pdbsum/25pv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=25pv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PAG_BACAN PAG_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax.
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</StructureSection>
[[Category: Bacillus anthracis]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Fan PF]]
[[Category: Yu CM]]