View source for 25su


==cryo-EM structure of human TAS2R4==
<StructureSection load='25su' size='340' side='right'caption='[[25su]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[25su]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=25SU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=25SU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=25su FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=25su OCA], [https://pdbe.org/25su PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=25su RCSB], [https://www.ebi.ac.uk/pdbsum/25su PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=25su ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TA2R4_HUMAN TA2R4_HUMAN] Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency.<ref>PMID:19628819</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Tan M]]
[[Category: Wu J]]