View source for 25yr


==High-resolution crystal structure of Arp2/3 complex inhibitor Arpin==
<StructureSection load='25yr' size='340' side='right'caption='[[25yr]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[25yr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=25YR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=25YR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=25yr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=25yr OCA], [https://pdbe.org/25yr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=25yr RCSB], [https://www.ebi.ac.uk/pdbsum/25yr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=25yr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ARPIN_DANRE ARPIN_DANRE] Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors (By similarity). Involved in steering cell migration by controlling its directional persistence.<ref>PMID:24132237</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Danio rerio]]
[[Category: Large Structures]]
[[Category: Liu L]]
[[Category: Wang M]]
[[Category: Ye S]]
[[Category: Zhang R]]
[[Category: Zhang X]]
[[Category: Zhu Y]]