View source for 26fe


==Cryo-EM structure of the A17(1-16) peptide-bound N-terminal 17 residue truncated D13 trimer from vaccinia virus==
<StructureSection load='26fe' size='340' side='right'caption='[[26fe]], [[Resolution|resolution]] 3.04&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[26fe]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=26FE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=26FE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.04&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=26fe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=26fe OCA], [https://pdbe.org/26fe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=26fe RCSB], [https://www.ebi.ac.uk/pdbsum/26fe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=26fe ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PG125_VACCW PG125_VACCW] Scaffold protein which forms a transitory spherical honeycomb lattice providing curvature and rigidity to the convex membrane of crescent and immature virions (IV). This association occurs concomitantly with viral membrane formation. Targeted by the drug rifampicin, which prevents the formation of this lattice, and hence virus morphogenesis. In the presence of rifampicin, irregularly shaped membranes that lack the honeycomb layer accumulate around areas of electron-dense viroplasm. This layer is lost from virions during maturation from IV to mature virion (MV), through the proteolysis of OPG158 N-terminus.<ref>PMID:19570860</ref> <ref>PMID:35361762</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Vaccinia virus]]
[[Category: Hyun JK]]
[[Category: Jang YT]]
[[Category: Jeong HS]]
[[Category: Jo DG]]
[[Category: Kang ES]]
[[Category: Kim SM]]
[[Category: Kim YH]]
[[Category: Lee SN]]
[[Category: Ryu BH]]
[[Category: Sul JH]]