View source for 26lk


==Cryo-EM structure of human LAS1L-NOL9 complex==
<StructureSection load='26lk' size='340' side='right'caption='[[26lk]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[26lk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=26LK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=26LK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=26lk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=26lk OCA], [https://pdbe.org/26lk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=26lk RCSB], [https://www.ebi.ac.uk/pdbsum/26lk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=26lk ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/LAS1L_HUMAN LAS1L_HUMAN] Spinal muscular atrophy with respiratory distress type 2;Wilson-Turner syndrome. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/LAS1L_HUMAN LAS1L_HUMAN] Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (PubMed:20647540). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (PubMed:22083961).<ref>PMID:20647540</ref> <ref>PMID:22083961</ref> <ref>PMID:22872859</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cheng J]]
[[Category: Li Y]]
[[Category: Zhu J]]