View source for 26vc


==Alpha-lipoic acid-bound SMVT in the occluded state==
<StructureSection load='26vc' size='340' side='right'caption='[[26vc]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[26vc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=26VC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=26VC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LPA:LIPOIC+ACID'>LPA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=26vc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=26vc OCA], [https://pdbe.org/26vc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=26vc RCSB], [https://www.ebi.ac.uk/pdbsum/26vc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=26vc ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SC5A6_HUMAN SC5A6_HUMAN] The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/SC5A6_HUMAN SC5A6_HUMAN] Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide (PubMed:10329687, PubMed:15561972, PubMed:19211916, PubMed:20980265, PubMed:21570947, PubMed:22015582, PubMed:25809983, PubMed:25971966, PubMed:27904971, PubMed:28052864, PubMed:31754459). Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake (PubMed:10329687, PubMed:20980265). Required for biotin and pantothenate uptake in the intestine across the brush border membrane (PubMed:19211916). Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (By similarity). Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier (PubMed:25809983).[UniProtKB:Q5U4D8]<ref>PMID:10329687</ref> <ref>PMID:15561972</ref> <ref>PMID:19211916</ref> <ref>PMID:20980265</ref> <ref>PMID:21570947</ref> <ref>PMID:22015582</ref> <ref>PMID:25809983</ref> <ref>PMID:25971966</ref> <ref>PMID:27904971</ref> <ref>PMID:28052864</ref> <ref>PMID:31754459</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Zhang Z]]
[[Category: Zhen Q]]