View source for 28oe


==Human PRC1.4 in complex with native UBCH5C bound to a H3Kc27me3 mononucleosome==
<StructureSection load='28oe' size='340' side='right'caption='[[28oe]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[28oe]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Xenopus Xenopus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=28OE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=28OE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.74&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=28oe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=28oe OCA], [https://pdbe.org/28oe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=28oe RCSB], [https://www.ebi.ac.uk/pdbsum/28oe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=28oe ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PHC2_HUMAN PHC2_HUMAN] Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Xenopus]]
[[Category: Ciapponi M]]
[[Category: Mueller J]]