View source for 29ou


==CBD fold in mouse injected with seeds of CBD==
<StructureSection load='29ou' size='340' side='right'caption='[[29ou]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[29ou]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus Mus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=29OU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=29OU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=29ou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=29ou OCA], [https://pdbe.org/29ou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=29ou RCSB], [https://www.ebi.ac.uk/pdbsum/29ou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=29ou ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/TAU_MOUSE TAU_MOUSE] May be involved in the pathogenesis of cytoplasmic inclusions (as Mallory bodies) in livers of mice chronically intoxicated with Griseofulvin or DDC (3,5-diethoxycarbonyl-2,4-dihydrocollidine), a model for human alcoholic hepatitis. Alteration of Tau (abnormal phosphorylation and cross-linking) could contribute to Mallory bodies formation and disturbance of microtubule function in alcoholic liver disease.
== Function ==
[https://www.uniprot.org/uniprot/TAU_MOUSE TAU_MOUSE] Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Mus]]
[[Category: Goedert M]]
[[Category: Lovestam SL]]
[[Category: Scheres SHW]]