View source for 29vy


==Structure of Tetrahydrocannabinolic acid synthase(THCAS) in complex with FAD==
<StructureSection load='29vy' size='340' side='right'caption='[[29vy]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[29vy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Cannabis_sativa Cannabis sativa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=29VY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=29VY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.33&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=29vy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=29vy OCA], [https://pdbe.org/29vy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=29vy RCSB], [https://www.ebi.ac.uk/pdbsum/29vy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=29vy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/THCAS_CANSA THCAS_CANSA] Catalyzes the oxidative cyclization of the monoterpene moiety in cannabigerolic acid (CBGA), producing delta(9)-tetrahydrocannabinolate (THCA), the major cannabioid in drug-type Cannabis plants. Can also use cannabinerolic acid as substrate, but not cannabigerol or cannabinerol.<ref>PMID:15190053</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Cannabis sativa]]
[[Category: Large Structures]]
[[Category: Cartwright J]]
[[Category: Domenech J]]
[[Category: Grogan G]]