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==SOLUTION NMR STRUCTURE OF A SUBSTRATE FOR THE ARCHAEAL PRE-TRNA SPLICING ENDONUCLEASES: THE BULGE-HELIX-BULGE MOTIF, MINIMIZED AVERAGE STRUCTURE==
<StructureSection load='2a9l' size='340' side='right'caption='[[2a9l]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2a9l]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A9L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A9L FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a9l OCA], [https://pdbe.org/2a9l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a9l RCSB], [https://www.ebi.ac.uk/pdbsum/2a9l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a9l ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
The structure of the bulge-helix-bulge motif that constitutes the intron/exon splice site in H. volcanii pre-tRNATrp has been determined by NMR spectroscopy. The conformations of the two 3 nt bulges, where the pre-tRNA is cleaved, are stabilized by stacking interactions between bulge nucleotides and bases in the adjacent Watson-Crick helices and by a network of backbone hydrogen bonds. Both bulges are presented on the same minor groove face of the central 4 bp helix, and the overall structure has approximate two-fold symmetry, which makes it well-suited for attack by archaeal splicing endonucleases, which are symmetric dimers.

Solution structure of a substrate for the archaeal pre-tRNA splicing endonucleases: the bulge-helix-bulge motif.,Diener JL, Moore PB Mol Cell. 1998 May;1(6):883-94. PMID:9660971<ref>PMID:9660971</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2a9l" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Diener JL]]
[[Category: Moore PB]]