View source for 2coz


==Solution structure of the CAP-Gly domain in human centrosome-associated protein CAP350==
<StructureSection load='2coz' size='340' side='right'caption='[[2coz]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2coz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2COZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2COZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2coz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2coz OCA], [https://pdbe.org/2coz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2coz RCSB], [https://www.ebi.ac.uk/pdbsum/2coz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2coz ProSAT], [https://www.topsan.org/Proteins/RSGI/2coz TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CE350_HUMAN CE350_HUMAN] Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity.<ref>PMID:15615782</ref> <ref>PMID:16314388</ref> <ref>PMID:17878239</ref> <ref>PMID:18412956</ref> <ref>PMID:19052644</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/2coz_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2coz ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Inoue M]]
[[Category: Kigawa T]]
[[Category: Koshiba S]]
[[Category: Saito K]]
[[Category: Yokoyama S]]