View source for 2cpd


==Solution structure of the RNA recognition motif of human APOBEC-1 complementation factor, ACF==
<StructureSection load='2cpd' size='340' side='right'caption='[[2cpd]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2cpd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CPD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpd OCA], [https://pdbe.org/2cpd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cpd RCSB], [https://www.ebi.ac.uk/pdbsum/2cpd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cpd ProSAT], [https://www.topsan.org/Proteins/RSGI/2cpd TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A1CF_HUMAN A1CF_HUMAN] Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay.<ref>PMID:10781591</ref> <ref>PMID:10669759</ref> <ref>PMID:12881431</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cp/2cpd_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cpd ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Inoue M]]
[[Category: Kigawa T]]
[[Category: Muto Y]]
[[Category: Nagata T]]
[[Category: Shirouzu M]]
[[Category: Terada T]]
[[Category: Yokoyama S]]