View source for 2cpw


==Solution structure of RSGI RUH-031, a UBA domain from human cDNA==
<StructureSection load='2cpw' size='340' side='right'caption='[[2cpw]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2cpw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CPW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpw OCA], [https://pdbe.org/2cpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cpw RCSB], [https://www.ebi.ac.uk/pdbsum/2cpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cpw ProSAT], [https://www.topsan.org/Proteins/RSGI/2cpw TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UBS3B_HUMAN UBS3B_HUMAN] Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.<ref>PMID:15159412</ref> <ref>PMID:17880946</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cp/2cpw_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cpw ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Hayashi F]]
[[Category: Hirota H]]
[[Category: Onuki H]]
[[Category: Ruhul Momen AZM]]
[[Category: Yokoyama S]]