View source for 2cto


==Solution structure of the HMG box like domain from human hypothetical protein FLJ14904==
<StructureSection load='2cto' size='340' side='right'caption='[[2cto]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2cto]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CTO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CTO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cto OCA], [https://pdbe.org/2cto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cto RCSB], [https://www.ebi.ac.uk/pdbsum/2cto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cto ProSAT], [https://www.topsan.org/Proteins/RSGI/2cto TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MAEL_HUMAN MAEL_HUMAN] Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuage (By similarity).
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Inoue M]]
[[Category: Kamatari YO]]
[[Category: Kigawa T]]
[[Category: Koshiba S]]
[[Category: Sato M]]
[[Category: Tomizawa T]]
[[Category: Yokoyama S]]