View source for 2cuf


==Solution structure of the homeobox domain of the human hypothetical protein FLJ21616==
<StructureSection load='2cuf' size='340' side='right'caption='[[2cuf]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2cuf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CUF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cuf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cuf OCA], [https://pdbe.org/2cuf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cuf RCSB], [https://www.ebi.ac.uk/pdbsum/2cuf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cuf ProSAT], [https://www.topsan.org/Proteins/RSGI/2cuf TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HMBX1_HUMAN HMBX1_HUMAN] Transcription factor. Isoform 1 acts as a transcriptional repressor. Isoform 4 has very low activity as a transcriptional repressor.<ref>PMID:16825764</ref> <ref>PMID:19757162</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cu/2cuf_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cuf ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Inoue M]]
[[Category: Kigawa T]]
[[Category: Koshiba S]]
[[Category: Ohnishi S]]
[[Category: Tomizawa T]]
[[Category: Yokoyama S]]