View source for 2dba


==The solution structure of the tetratrico peptide repeat of human Smooth muscle cell associated protein-1, isoform 2==
<StructureSection load='2dba' size='340' side='right'caption='[[2dba]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2dba]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DBA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DBA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dba OCA], [https://pdbe.org/2dba PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dba RCSB], [https://www.ebi.ac.uk/pdbsum/2dba PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dba ProSAT], [https://www.topsan.org/Proteins/RSGI/2dba TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UN45A_HUMAN UN45A_HUMAN] Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity).<ref>PMID:12119110</ref> <ref>PMID:16478993</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/db/2dba_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dba ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Inoue M]]
[[Category: Kigawa T]]
[[Category: Koshiba S]]
[[Category: Sasagawa A]]
[[Category: Tochio N]]
[[Category: Yokoyama S]]