View source for 2dbh


==Solution structure of the carboxyl-terminal CARD-like domain in human TNFR-related death receptor-6==
<StructureSection load='2dbh' size='340' side='right'caption='[[2dbh]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2dbh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DBH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DBH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dbh OCA], [https://pdbe.org/2dbh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dbh RCSB], [https://www.ebi.ac.uk/pdbsum/2dbh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dbh ProSAT], [https://www.topsan.org/Proteins/RSGI/2dbh TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TNR21_HUMAN TNR21_HUMAN] May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).

==See Also==
*[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Inoue M]]
[[Category: Kigawa T]]
[[Category: Koshiba S]]
[[Category: Saito K]]
[[Category: Yokoyama S]]