View source for 2dgx


==Solution structure of the RNA recognition motif in KIAA0430 protein==
<StructureSection load='2dgx' size='340' side='right'caption='[[2dgx]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2dgx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DGX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DGX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dgx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dgx OCA], [https://pdbe.org/2dgx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dgx RCSB], [https://www.ebi.ac.uk/pdbsum/2dgx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dgx ProSAT], [https://www.topsan.org/Proteins/RSGI/2dgx TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MARF1_HUMAN MARF1_HUMAN] Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity).
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Abe C]]
[[Category: Inoue M]]
[[Category: Kigawa T]]
[[Category: Muto Y]]
[[Category: Shirouzu M]]
[[Category: Terada T]]
[[Category: Yokoyama S]]