View source for 2dlw


==Solution structure of the IRS domain of human docking protein 2, isoform a==
<StructureSection load='2dlw' size='340' side='right'caption='[[2dlw]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2dlw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DLW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dlw OCA], [https://pdbe.org/2dlw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dlw RCSB], [https://www.ebi.ac.uk/pdbsum/2dlw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dlw ProSAT], [https://www.topsan.org/Proteins/RSGI/2dlw TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DOK2_HUMAN DOK2_HUMAN] DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dl/2dlw_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dlw ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Hayashi F]]
[[Category: Kurosaki C]]
[[Category: Yokoyama S]]
[[Category: Yoshida M]]
[[Category: Zhang HP]]