View source for 2dmy


==Solution structure of DSRM domain in Spermatid perinuclear RNA-bind protein==
<StructureSection load='2dmy' size='340' side='right'caption='[[2dmy]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2dmy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DMY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DMY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dmy OCA], [https://pdbe.org/2dmy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dmy RCSB], [https://www.ebi.ac.uk/pdbsum/2dmy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dmy ProSAT], [https://www.topsan.org/Proteins/RSGI/2dmy TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/STRBP_HUMAN STRBP_HUMAN] Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dm/2dmy_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dmy ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: He F]]
[[Category: Inoue M]]
[[Category: Kadirvel S]]
[[Category: Kigawa T]]
[[Category: Muto Y]]
[[Category: Shirouzu M]]
[[Category: Terada T]]
[[Category: Yokoyama S]]