View source for 2ect


==Solution structure of the Zinc finger, C3HC4 type (RING finger) domain of RING finger protein 126==
<StructureSection load='2ect' size='340' side='right'caption='[[2ect]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ect]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ECT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ect FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ect OCA], [https://pdbe.org/2ect PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ect RCSB], [https://www.ebi.ac.uk/pdbsum/2ect PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ect ProSAT], [https://www.topsan.org/Proteins/RSGI/2ect TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RN126_MOUSE RN126_MOUSE] E3 ubiquitin-protein ligase. By ubiquitinating CDKN1A/p21 and targeting it for proteasomal degradation, may promote cell proliferation (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2ect_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ect ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Abe H]]
[[Category: Kigawa T]]
[[Category: Miyamoto K]]
[[Category: Tochio N]]
[[Category: Yokoyama S]]