View source for 2ecw


==Solution structure of the Zinc finger, C3HC4 type (RING finger) domain Tripartite motif protein 30==
<StructureSection load='2ecw' size='340' side='right'caption='[[2ecw]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ecw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ECW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ecw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecw OCA], [https://pdbe.org/2ecw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ecw RCSB], [https://www.ebi.ac.uk/pdbsum/2ecw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ecw ProSAT], [https://www.topsan.org/Proteins/RSGI/2ecw TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TR30A_MOUSE TR30A_MOUSE] Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain. May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences. Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination. Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex. This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18. No activity detected against a range of retroviruses including a number of lentiviruses, gammaretroviruses and betaretroviruses.<ref>PMID:18345001</ref> <ref>PMID:19147168</ref> <ref>PMID:21048113</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2ecw_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ecw ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Abe H]]
[[Category: Kigawa T]]
[[Category: Miyamoto K]]
[[Category: Tochio N]]
[[Category: Yokoyama S]]
[[Category: Yoneyama M]]