View source for 2ewl


==Solution structure of the C-terminal domain (monomer) of the HPV45 oncoprotein E7==
<StructureSection load='2ewl' size='340' side='right'caption='[[2ewl]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ewl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_45 Human papillomavirus 45]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EWL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ewl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ewl OCA], [https://pdbe.org/2ewl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ewl RCSB], [https://www.ebi.ac.uk/pdbsum/2ewl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ewl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VE7_HPV45 VE7_HPV45] E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ew/2ewl_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ewl ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Human papillomavirus 45]]
[[Category: Large Structures]]
[[Category: Gorlach M]]
[[Category: Ohlenschlager O]]