View source for 2fc6


==Solution structure of the zf-CCCH domain of target of EGR1, member 1 (Nuclear)==
<StructureSection load='2fc6' size='340' side='right'caption='[[2fc6]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2fc6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FC6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fc6 OCA], [https://pdbe.org/2fc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fc6 RCSB], [https://www.ebi.ac.uk/pdbsum/2fc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fc6 ProSAT], [https://www.topsan.org/Proteins/RSGI/2fc6 TOPSAN]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/TOE1_HUMAN TOE1_HUMAN] Pontocerebellar hypoplasia type 7. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/TOE1_HUMAN TOE1_HUMAN] Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684).<ref>PMID:12562764</ref> <ref>PMID:28092684</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Dang W]]
[[Category: Inoue M]]
[[Category: Kigawa T]]
[[Category: Muto Y]]
[[Category: Shirouzu M]]
[[Category: Terada T]]
[[Category: Yokoyama S]]