View source for 2fy1


==A dual mode of RNA recognition by the RBMY protein==
<StructureSection load='2fy1' size='340' side='right'caption='[[2fy1]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2fy1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FY1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FY1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fy1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fy1 OCA], [https://pdbe.org/2fy1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fy1 RCSB], [https://www.ebi.ac.uk/pdbsum/2fy1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fy1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RBY1A_HUMAN RBY1A_HUMAN] RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs.<ref>PMID:8269511</ref> <ref>PMID:12165565</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fy/2fy1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fy1 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Allain FHT]]
[[Category: Bourgois C]]
[[Category: Elliot D]]
[[Category: Kister L]]
[[Category: Skrisovska L]]
[[Category: Stefl R]]
[[Category: Stevenin J]]
[[Category: Wenter P]]