View source for 2i0x


==Hypothetical protein PF1117 from Pyrococcus furiosus==
<StructureSection load='2i0x' size='340' side='right'caption='[[2i0x]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2i0x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I0X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I0X FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i0x OCA], [https://pdbe.org/2i0x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i0x RCSB], [https://www.ebi.ac.uk/pdbsum/2i0x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i0x ProSAT], [https://www.topsan.org/Proteins/SECSG/2i0x TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAS2_PYRFU CAS2_PYRFU] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.[HAMAP-Rule:MF_01471]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i0/2i0x_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i0x ConSurf].
<div style="clear:both"></div>

==See Also==
*[[CRISPR-Cas|CRISPR-Cas]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pyrococcus furiosus]]
[[Category: Chen LQ]]
[[Category: Fu Z-Q]]
[[Category: Liu Z-J]]
[[Category: Rose JP]]
[[Category: Wang BC]]