View source for 2ife


==TRANSLATION INITIATION FACTOR IF3 FROM ESCHERICHIA COLI RIBOSOME BINDING DOMAIN (RESIDUES 84-180)==
<StructureSection load='2ife' size='340' side='right'caption='[[2ife]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ife]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ife 1ife]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IFE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IFE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ife FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ife OCA], [https://pdbe.org/2ife PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ife RCSB], [https://www.ebi.ac.uk/pdbsum/2ife PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ife ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IF3_ECOLI IF3_ECOLI] IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.[HAMAP-Rule:MF_00080]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/if/2ife_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ife ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Dardel F]]
[[Category: De Cock E]]
[[Category: Garcia C]]