View source for 2iii


==Crystal structure of the adenosylmethionine decarboxylase (aq_254) from aquifex aeolicus vf5==
<StructureSection load='2iii' size='340' side='right'caption='[[2iii]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2iii]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus_VF5 Aquifex aeolicus VF5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2III OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2III FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iii OCA], [https://pdbe.org/2iii PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iii RCSB], [https://www.ebi.ac.uk/pdbsum/2iii PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iii ProSAT], [https://www.topsan.org/Proteins/RSGI/2iii TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SPEH_AQUAE SPEH_AQUAE] Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ii/2iii_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iii ConSurf].
<div style="clear:both"></div>

==See Also==
*[[SAM decarboxylase|SAM decarboxylase]]
__TOC__
</StructureSection>
[[Category: Aquifex aeolicus VF5]]
[[Category: Large Structures]]
[[Category: Baba S]]
[[Category: Ebihara A]]
[[Category: Jeyakanthan J]]
[[Category: Kanaujia SP]]
[[Category: Kuramitsu S]]
[[Category: Sekar K]]
[[Category: Shinkai A]]
[[Category: Shiro Y]]
[[Category: Vasuki Ranjani C]]
[[Category: Yokoyama S]]