View source for 2jii


==Structure of vaccinia related kinase 3==
<StructureSection load='2jii' size='340' side='right'caption='[[2jii]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2jii]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JII OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JII FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jii OCA], [https://pdbe.org/2jii PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jii RCSB], [https://www.ebi.ac.uk/pdbsum/2jii PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jii ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VRK3_HUMAN VRK3_HUMAN] Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus.<ref>PMID:14645249</ref> <ref>PMID:19141289</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ji/2jii_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jii ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bunkoczi G]]
[[Category: Burgess-Brown N]]
[[Category: Cooper C]]
[[Category: Edwards A]]
[[Category: Eswaran J]]
[[Category: Fedorov O]]
[[Category: Keates T]]
[[Category: Knapp S]]
[[Category: Pike ACW]]
[[Category: Salah E]]
[[Category: Savitsky P]]
[[Category: Sobott F]]
[[Category: Sundstrom M]]
[[Category: Ugochukwu E]]
[[Category: Uppenberg J]]
[[Category: Weigelt J]]
[[Category: Von Delft F]]