View source for 2jo7


==Solution structure of the adhesion protein Bd37 from Babesia divergens==
<StructureSection load='2jo7' size='340' side='right'caption='[[2jo7]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2jo7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Babesia_divergens Babesia divergens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JO7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jo7 OCA], [https://pdbe.org/2jo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jo7 RCSB], [https://www.ebi.ac.uk/pdbsum/2jo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jo7 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8T117_BABDI Q8T117_BABDI] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Babesia divergens is the Apicomplexa agent of the bovine babesiosis in Europe: this infection leads to growth and lactation decrease, so that economical losses due to this parasite are sufficient to require the development of a vaccine. The major surface antigen of B. divergens has been described as a 37 kDa protein glycosyl phosphatidyl inositol (GPI)-anchored at the surface of the merozoite. The immuno-prophylactic potential of Bd37 has been demonstrated, and we present here the high-resolution solution structure of the 27 kDa structured core of Bd37 (Delta-Bd37) using NMR spectroscopy. A model for the whole protein has been obtained using additional small angle X-ray scattering (SAXS) data. The knowledge of the 3D structure of Bd37 allowed the precise epitope mapping of antibodies on its surface. Interestingly, the geometry of Delta-Bd37 reveals an intriguing similarity with the exocyst subunit Exo84p C-terminal region, an eukaryotic protein that has a direct implication in vesicle trafficking. This strongly suggests that Apicomplexa have developed in parallel molecular machines similar in structure and function to the ones used for endo- and exocytosis in eukaryotic cells.

The solution structure of the adhesion protein Bd37 from Babesia divergens reveals structural homology with eukaryotic proteins involved in membrane trafficking.,Delbecq S, Auguin D, Yang YS, Lohr F, Arold S, Schetters T, Precigout E, Gorenflot A, Roumestand C J Mol Biol. 2008 Jan 11;375(2):409-24. Epub 2007 Aug 21. PMID:18035372<ref>PMID:18035372</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2jo7" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Babesia divergens]]
[[Category: Large Structures]]
[[Category: Arold S]]
[[Category: Auguin D]]
[[Category: Delbecq S]]
[[Category: Gorenflot A]]
[[Category: Lohr F]]
[[Category: Precigout E]]
[[Category: Roumestand C]]
[[Category: Schetters T]]
[[Category: Yang Y]]