View source for 2jsk


==Monomeric Human Telomere DNA Tetraplex with 3+1 Strand Fold Topology, Two Edgewise Loops and Double-Chain Reversal Loop, 16 G Form 1, NMR, 10 Structures==
<StructureSection load='2jsk' size='340' side='right'caption='[[2jsk]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2jsk]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JSK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGM:8-BROMO-2-DEOXYGUANOSINE-5-MONOPHOSPHATE'>BGM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsk OCA], [https://pdbe.org/2jsk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jsk RCSB], [https://www.ebi.ac.uk/pdbsum/2jsk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsk ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
Intramolecular G-quadruplexes formed by human telomere sequences are attractive anticancer targets. Recently, four-repeat human telomere sequences have been shown to form two different intramolecular (3 + 1) G-quadruplexes in K(+) solution (Form 1 and Form 2). Here we report on the solution structures of both Form 1 and Form 2 adopted by natural human telomere sequences. Both structures contain the (3 + 1) G-tetrad core with one double-chain-reversal and two edgewise loops, but differ in the successive order of loop arrangements within the G-quadruplex scaffold. Our results provide the structural details at the two ends of the G-tetrad core in the context of natural sequences and information on different loop conformations. This structural information might be important for our understanding of telomere G-quadruplex structures and for anticancer drug design targeted to such scaffolds.

Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution.,Phan AT, Kuryavyi V, Luu KN, Patel DJ Nucleic Acids Res. 2007;35(19):6517-25. Epub 2007 Sep 25. PMID:17895279<ref>PMID:17895279</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2jsk" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Kuryavyi VV]]
[[Category: Luu KN]]
[[Category: Patel DJ]]
[[Category: Phan AT]]