View source for 2k1g


==Solution NMR structure of lipoprotein spr from Escherichia coli K12. Northeast Structural Genomics target ER541-37-162==
<StructureSection load='2k1g' size='340' side='right'caption='[[2k1g]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2k1g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2jyx 2jyx]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K1G FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k1g OCA], [https://pdbe.org/2k1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k1g RCSB], [https://www.ebi.ac.uk/pdbsum/2k1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k1g ProSAT], [https://www.topsan.org/Proteins/NESGC/2k1g TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MEPS_ECOLI MEPS_ECOLI] A murein DD-endopeptidase with specificity for D-Ala-meso-diaminopimelic acid (mDAP) cross-links. Its role is probably to cleave D-Ala-mDAP cross-links to allow insertion of new glycans and thus cell wall expansion. Functionally redundant with MepM and MepH. Also has weak LD-carboxypeptidase activity on L-mDAP-D-Ala peptide bonds. Partially suppresses a prc disruption mutant.<ref>PMID:23062283</ref> <ref>PMID:9158724</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k1/2k1g_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k1g ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Acton TB]]
[[Category: Aramini JM]]
[[Category: Baran MC]]
[[Category: Huang YJ]]
[[Category: Jiang M]]
[[Category: Liu J]]
[[Category: Maglaqui M]]
[[Category: Montelione GT]]
[[Category: Rossi P]]
[[Category: Rost B]]
[[Category: Swapna GVT]]
[[Category: Xiao R]]
[[Category: Zhao L]]