View source for 2kbm


==Ca-S100A1 interacting with TRTK12==
<StructureSection load='2kbm' size='340' side='right'caption='[[2kbm]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2kbm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KBM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kbm OCA], [https://pdbe.org/2kbm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kbm RCSB], [https://www.ebi.ac.uk/pdbsum/2kbm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kbm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAZA2_RAT CAZA2_RAT] F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kb/2kbm_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kbm ConSurf].
<div style="clear:both"></div>

==See Also==
*[[F-actin capping protein|F-actin capping protein]]
*[[S100 proteins 3D structures|S100 proteins 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Cannon BR]]
[[Category: Morgan M]]
[[Category: Varney KM]]
[[Category: Weber DJ]]
[[Category: Wright NT]]