View source for 2kd3


==NMR structure of the Wnt modulator protein Sclerostin==
<StructureSection load='2kd3' size='340' side='right'caption='[[2kd3]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2kd3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KD3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kd3 OCA], [https://pdbe.org/2kd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kd3 RCSB], [https://www.ebi.ac.uk/pdbsum/2kd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kd3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SOST_MOUSE SOST_MOUSE] Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.<ref>PMID:19419300</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kd/2kd3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kd3 ConSurf].
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== Publication Abstract from PubMed ==
Sclerostin has been identified as a negative regulator of bone growth. Initially it was considered that Sclerostin performs its regulatory function via acting as a modulator of bone morphogenetic proteins (BMPs) similar to known examples such as Noggin, Chordin, and members of the DAN family. Recent findings, however, show that Sclerostin interferes with the Wnt signaling pathway due to binding to the Wnt co-receptor LRP5 thereby modulating bone growth. As Sclerostin is exclusively produced by osteocytes located in bones, neutralization of its bone-inhibiting functions makes it a highly interesting target for an osteoanabolic therapeutic approach in diseases characterized by bone loss, such as osteoporosis. Despite the huge interest in Sclerostin inhibitors the molecular basis of its function and its interaction with components of the Wnt signaling cascade has remained unclear. Here, we present the NMR structure of murine Sclerostin providing the first insights how Sclerostin might bind to LRP5.

NMR structure of the Wnt modulator protein Sclerostin.,Weidauer SE, Schmieder P, Beerbaum M, Schmitz W, Oschkinat H, Mueller TD Biochem Biophys Res Commun. 2009 Feb 27;380(1):160-5. Epub 2009 Jan 21. PMID:19166819<ref>PMID:19166819</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mueller TD]]
[[Category: Weidauer SE]]