View source for 2kfp


==Solution NMR structure of PSPTO_3016 from Pseudomonas syringae. Northeast Structural Genomics Consortium target PsR293.==
<StructureSection load='2kfp' size='340' side='right'caption='[[2kfp]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2kfp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_syringae_pv._tomato Pseudomonas syringae pv. tomato]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KFP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kfp OCA], [https://pdbe.org/2kfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kfp RCSB], [https://www.ebi.ac.uk/pdbsum/2kfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kfp ProSAT], [https://www.topsan.org/Proteins/NESGC/2kfp TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q880Y4_PSESM Q880Y4_PSESM] 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kf/2kfp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kfp ConSurf].
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== Publication Abstract from PubMed ==
The protein Pspto_3016 is a 117-residue member of the protein domain family PF04237 (DUF419), which is to date a functionally uncharacterized family of proteins. In this report, we describe the structure of Pspto_3016 from Pseudomonas syringae solved by both solution NMR and X-ray crystallography at 2.5 A resolution. In both cases, the structure of Pspto_3016 adopts a "double wing" alpha/beta sandwich fold similar to that of protein YjbR from Escherichia coli and to the C-terminal DNA binding domain of the MotA transcription factor (MotCF) from T4 bacteriophage, along with other uncharacterized proteins. Pspto_3016 was selected by the Protein Structure Initiative of the National Institutes of Health and the Northeast Structural Genomics Consortium (NESG ID PsR293).

Solution NMR and X-ray crystal structures of Pseudomonas syringae Pspto_3016 from protein domain family PF04237 (DUF419) adopt a "double wing" DNA binding motif.,Feldmann EA, Seetharaman J, Ramelot TA, Lew S, Zhao L, Hamilton K, Ciccosanti C, Xiao R, Acton TB, Everett JK, Tong L, Montelione GT, Kennedy MA J Struct Funct Genomics. 2012 Sep;13(3):155-62. Epub 2012 Aug 3. PMID:22865330<ref>PMID:22865330</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2kfp" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas syringae pv. tomato]]
[[Category: Acton TB]]
[[Category: Ciccosanti C]]
[[Category: Everett JK]]
[[Category: Feldmann EA]]
[[Category: Hamilton K]]
[[Category: Kennedy MA]]
[[Category: Montelione GT]]
[[Category: Nair R]]
[[Category: Ramelot TA]]
[[Category: Rost B]]
[[Category: Swapna G]]
[[Category: Xiao R]]
[[Category: Zhao L]]