View source for 2kgs


==Solution structure of the amino-terminal domain of OmpATb, a pore forming protein from Mycobacterium tuberculosis==
<StructureSection load='2kgs' size='340' side='right'caption='[[2kgs]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2kgs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KGS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kgs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kgs OCA], [https://pdbe.org/2kgs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kgs RCSB], [https://www.ebi.ac.uk/pdbsum/2kgs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kgs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ARFA_MYCTU ARFA_MYCTU] Probably plays a role in ammonia secretion that neutralizes the medium at pH 5.5, although it does not play a direct role in ammonia transport. The OmpA-like domain (196-326) binds M.tuberculosis peptidoglycan. Overexpression in M.bovis or M.smegmatis gives channels with average conductance value of 1,600 +/- 100 pS, but this may not be physiologically relevant.<ref>PMID:12366842</ref> <ref>PMID:17573469</ref> <ref>PMID:21410778</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Auguin D]]
[[Category: Delbecq S]]
[[Category: Dumas E]]
[[Category: Molle V]]
[[Category: Saint N]]
[[Category: Yang Y]]