View source for 2kji


==A divergent ins protein in c. elegans structurally resemble insulin and activates the human insulin receptor==
<StructureSection load='2kji' size='340' side='right'caption='[[2kji]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2kji]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KJI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kji OCA], [https://pdbe.org/2kji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kji RCSB], [https://www.ebi.ac.uk/pdbsum/2kji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kji ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ILB5_CAEEL ILB5_CAEEL] 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kj/2kji_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kji ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Caenorhabditis elegans contains a family of putative insulin-like genes proposed to regulate dauer arrest and senescence. These sequences often lack characteristic sequence features of human insulin essential for its folding, structure, and function. Here, we describe the structure and receptor-binding properties of INS-6, a single-chain polypeptide expressed in specific neurons. Despite multiple nonconservative changes in sequence, INS-6 recapitulates an insulin-like fold. Although lacking classical receptor-binding determinants, INS-6 binds to and activates the human insulin receptor. Its activity is greater than that of an analogous single-chain human insulin analog.

A divergent INS protein in Caenorhabditis elegans structurally resembles human insulin and activates the human insulin receptor.,Hua QX, Nakagawa SH, Wilken J, Ramos RR, Jia W, Bass J, Weiss MA Genes Dev. 2003 Apr 1;17(7):826-31. doi: 10.1101/gad.1058003. Epub 2003 Mar 21. PMID:12654724<ref>PMID:12654724</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2kji" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Large Structures]]
[[Category: Bass J]]
[[Category: Hua QX]]
[[Category: Jia WH]]
[[Category: Nakarawa SH]]
[[Category: Ramos RR]]
[[Category: Weiss MA]]
[[Category: Wilken R]]