View source for 2kk2


==NMR solution structure of the pheromone En-A1 from Euplotes nobilii==
<StructureSection load='2kk2' size='340' side='right'caption='[[2kk2]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2kk2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Euplotes_nobilii Euplotes nobilii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KK2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kk2 OCA], [https://pdbe.org/2kk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kk2 RCSB], [https://www.ebi.ac.uk/pdbsum/2kk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kk2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/C4NXD5_EUPNO C4NXD5_EUPNO] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Wild-type strains of the protozoan ciliate Euplotes collected from different locations on the coasts of Antarctica, Tierra del Fuego and the Arctic were taxonomically identified as the morpho-species Euplotes nobilii, based on morphometric and phylogenetic analyses. Subsequent studies of their sexual interactions revealed that mating combinations of Antarctic and Arctic strains form stable pairs of conjugant cells. These conjugant pairs were isolated and shown to complete mutual gene exchange and cross-fertilization. The biological significance of this finding was further substantiated by demonstrating that close homology exists among the three-dimensional structures determined by NMR of the water-borne signaling pheromones that are constitutively secreted into the extracellular space by these interbreeding strains, in which these molecules trigger the switch between the growth stage and the sexual stage of the life cycle. The fact that Antarctic and Arctic E. nobilii populations share the same gene pool and belong to the same biological species provides new support to the biogeographic model of global distribution of eukaryotic microorganisms, which had so far been based exclusively on studies of morphological and phylogenetic taxonomy.

Antarctic and Arctic populations of the ciliate Euplotes nobilii show common pheromone-mediated cell-cell signaling and cross-mating.,Di Giuseppe G, Erra F, Dini F, Alimenti C, Vallesi A, Pedrini B, Wuthrich K, Luporini P Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3181-6. Epub 2011 Feb 7. PMID:21300903<ref>PMID:21300903</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2kk2" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Euplotes nobilii]]
[[Category: Large Structures]]
[[Category: Alimenti C]]
[[Category: Luporini P]]
[[Category: Pedrini B]]
[[Category: Vallesi A]]
[[Category: Wuthrich K]]