View source for 2kkt


==Solution structure of the SCA7 domain of human Ataxin-7-L3 protein==
<StructureSection load='2kkt' size='340' side='right'caption='[[2kkt]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2kkt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KKT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kkt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kkt OCA], [https://pdbe.org/2kkt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kkt RCSB], [https://www.ebi.ac.uk/pdbsum/2kkt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kkt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AT7L3_HUMAN AT7L3_HUMAN] Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex.[HAMAP-Rule:MF_03047]<ref>PMID:18206972</ref> <ref>PMID:21746879</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Atkinson AR]]
[[Category: Bonnet J]]
[[Category: Kieffer B]]
[[Category: Romier C]]
[[Category: Wang Y]]