View source for 2klr


==Solid-state NMR structure of the alpha-crystallin domain in alphaB-crystallin oligomers==
<StructureSection load='2klr' size='340' side='right'caption='[[2klr]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2klr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KLR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KLR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2klr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2klr OCA], [https://pdbe.org/2klr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2klr RCSB], [https://www.ebi.ac.uk/pdbsum/2klr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2klr ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN] Posterior polar cataract;Alpha-crystallinopathy;Zonular cataract;Familial isolated dilated cardiomyopathy;Fatal infantile hypertonic myofibrillar myopathy. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN] May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/2klr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2klr ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Art:Focusing on Crystallin|Art:Focusing on Crystallin]]
*[[Crystallin 3D structures|Crystallin 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bardiaux B]]
[[Category: Higman VA]]
[[Category: Jehle S]]
[[Category: Klevit RE]]
[[Category: Kuehne R]]
[[Category: Markovic S]]
[[Category: Oschkinat H]]
[[Category: Rajagopal P]]
[[Category: Van Rossum B]]