View source for 2ko8


==The Structure of Anti-TRAP==
<StructureSection load='2ko8' size='340' side='right'caption='[[2ko8]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ko8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KO8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ko8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ko8 OCA], [https://pdbe.org/2ko8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ko8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ko8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ko8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RTPA_BACSU RTPA_BACSU] By forming a complex with tryptophan-activated TRAP, and masking its RNA binding site, it inhibits TRAP's RNA binding ability, thereby abolishing TRAP regulation of gene expression, leading to antitermination and increased trp operon expression. AT acts by competing with messenger RNA for the RNA binding domain of TRAP.
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</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Large Structures]]
[[Category: Foster MP]]
[[Category: Gollnick P]]
[[Category: McElroy CA]]