View source for 2kpe


==Refined structure of Glycophorin A transmembrane segment dimer in DPC micelles==
<StructureSection load='2kpe' size='340' side='right'caption='[[2kpe]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2kpe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KPE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KPE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kpe OCA], [https://pdbe.org/2kpe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kpe RCSB], [https://www.ebi.ac.uk/pdbsum/2kpe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kpe ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GLPA_HUMAN GLPA_HUMAN] Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).<ref>PMID:8009226</ref> <ref>PMID:10926825</ref> <ref>PMID:12813056</ref> <ref>PMID:14604989</ref> <ref>PMID:15331714</ref> <ref>PMID:19438409</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arseniev AS]]
[[Category: Bocharov EV]]
[[Category: Efremov RG]]
[[Category: Goncharuk MV]]
[[Category: Mineev KS]]
[[Category: Volynsky PE]]