View source for 2kpz


==Human NEDD4 3RD WW Domain Complex with The Human T-cell Leukemia virus 1 GAG-Pro poliprotein Derived Peptide SDPQIPPPYVEP==
<StructureSection load='2kpz' size='340' side='right'caption='[[2kpz]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2kpz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/HTLV-1_isolate_Mel_15 HTLV-1 isolate Mel 15] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KPZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KPZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kpz OCA], [https://pdbe.org/2kpz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kpz RCSB], [https://www.ebi.ac.uk/pdbsum/2kpz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kpz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NEDD4_HUMAN NEDD4_HUMAN] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2.<ref>PMID:17218260</ref> <ref>PMID:18562292</ref> <ref>PMID:20086093</ref> <ref>PMID:21765395</ref> <ref>PMID:21399620</ref> 

==See Also==
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: HTLV-1 isolate Mel 15]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Blanco FJ]]
[[Category: Bonet R]]
[[Category: Cobos ES]]
[[Category: Iglesias-Bexiga M]]
[[Category: Luque I]]
[[Category: Macias M]]