View source for 2ksg


==Solution structure of dermcidin-1L, a human antibiotic peptide==
<StructureSection load='2ksg' size='340' side='right'caption='[[2ksg]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ksg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KSG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KSG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ksg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ksg OCA], [https://pdbe.org/2ksg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ksg RCSB], [https://www.ebi.ac.uk/pdbsum/2ksg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ksg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DCD_HUMAN DCD_HUMAN] DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity.<ref>PMID:17448443</ref>   Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.<ref>PMID:17448443</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Jung H]]
[[Category: Kim J]]
[[Category: Yang S]]